Group sequential testing
Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. Research in group sequential analysis has progressed rapidly over the past 20 years. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models.
Group sequential testing how to#
The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings.
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Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. For both formats the functionality available will depend on how you access the ebook (via Bookshelf Online in your browser or via the Bookshelf app on your PC or mobile device).
Group sequential testing pdf#
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